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2009

Trinh BX, Tjalma WAA, Vermeulen PB, Van den Eynden GG, Van der Auwera I, Van Laere SJ, Helleman J, Berns EMJJ, Dirix LY and van Dam PA. The VEGF pathway and the AKT/mTOR/p70S6K1 signalling pathway in human epithelial ovarian cancer.
Br J Cancer 2009 in press.

2008

Van Laere S, Beissbarth T, Van der Auwera I, Van den Eynden G, Trinh XB, Elst H, Van Hummelen P, van Dam P, Van Marck E, Vermeulen P, Dirix L. Relapse-free survival in breast cancer patients is associated with a gene expression signature characteristic for inflammatory breast cancer.
Clin Cancer Res. 2008 Nov 15;14(22):7452-60.

Van der Auwera I, Van Laere SJ, Van den Bosch SM, Van den Eynden GG, Trinh BX, van Dam PA, Colpaert CG, van Engeland M, Van Marck EA, Vermeulen PB, Dirix LY. Aberrant methylation of the Adenomatous Polyposis Coli (APC) gene promoter is associated with the inflammatory breast cancer phenotype.
Br J Cancer. 2008 Nov 18;99(10):1735-42.

Van den Eynden GG, Smid M, Van Laere SJ, Colpaert CG, Van der Auwera I, Bich TX, van Dam P, den Bakker MA, Dirix LY, Van Marck EA, Vermeulen PB, Foekens JA. Gene expression profiles associated with the presence of a fibrotic focus and the growth pattern in lymph node-negative breast cancer.
Clin Cancer Res. 2008 May 15;14(10):2944-52.

2007

Van den Eynden GG, Vandenberghe MK, van Dam PJ, Colpaert CG, van Dam P, Dirix LY, Vermeulen PB, Van Marck EA. Increased sentinel lymph node lymphangiogenesis is associated with nonsentinel axillary lymph node involvement in breast cancer patients with a positive sentinel node. Clin Cancer Res. 2007 Sep 15;13(18 Pt 1):5391-7.

Van Laere S, Van der Auwera I, Van den Eynden G, Van Hummelen P, van Dam P, Van Marck E, Vermeulen PB, Dirix L. Distinct molecular phenotype of inflammatory breast cancer compared to non-inflammatory breast cancer using Affymetrix-based genome-wide gene-expression analysis. Br J Cancer. 2007 Oct 22;97(8):1165-74

Van den Eynden GG, Van der Auwera I, Colpaert CG, Dirix LY, Van Marck EA, Vermeulen PB. Letter to the editor: Lymphangiogenesis in primary breast cancer. Cancer Lett. 2007 Oct 28;256(2):279-81; author reply 283-4.

Van Laere SJ, Van der Auwera I, Van den Eynden GG, van Dam P, Van Marck EA, Vermeulen PB, Dirix LY. NF-kappaB activation in inflammatory breast cancer is associated with oestrogen receptor downregulation, secondary to EGFR and/or ErbB2 overexpression and MAPK hyperactivation. Br J Cancer. 2007 Sep 3;97(5):659-69.

Van den Eynden GG, Van der Auwera I, Van Laere SJ, Trinh XB, Colpaert CG, van Dam P, Dirix LY, Vermeulen PB, Van Marck EA. Comparison of molecular determinants of angiogenesis and lymphangiogenesis in lymph node metastases and in primary tumours of patients with breast cancer. J Pathol. 2007 Sep;213(1):56-64.

Van den Eynden GG, Colpaert CG, Couvelard A, Pezzella F, Dirix LY, Vermeulen PB, Van Marck EA, Hasebe T. A fibrotic focus is a prognostic factor and a surrogate marker for hypoxia and (lymph)angiogenesis in breast cancer: review of the literature and proposal on the criteria of evaluation. Histopathology. 2007 Oct;51(4):440-51.

Van den Eynden GG, Van Laere SJ, Van der Auwera I, Gilles L, Burn JL, Colpaert C, van Dam P, Van Marck EA, Dirix LY and Vermeulen PB. Differential expression of hypoxia and (lymph)angiogenesis-related genes at different metastatic sites in breast cancer. Clin Exp Metastasis 2007 Feb 13

2006

Van den Eynden GG, Neyret A, Furney G, Rizk-Rabin M, Vermeulen PB, Bouizar Z, Body JJ and Dirix LY. PTHrP, calcitonin and calcitriol in a case of severe, protracted and refractory hypercalcemia due to a pancreatic neuroendocrine tumor. Bone 2006 Dec 21

Van den Eynden GG, Van der Auwera I, Van Laere SJ, Huygelen V, Colpaert CG, van Dam P, Dirix LY, Vermeulen PB and Van Marck EA. Induction of lymphangiogenesis in and around axillary lymph node metastases of patients with breast cancer. Br J Cancer 2006 Nov 20; 95(10): 1362-6

Van der Auwera I, Cao Y, Tille JC, Pepper MS, Jackson DG, Fox SB, Harris AL, Dirix LY and Vermeulen PB. First international consensus on the methodology of lymphangiogenesis quantification in solid human tumours. Br J Cancer 2006 Dec 18;95(12):1611-25

Vermeulen PB, Van Laere SL, Dirix LY. How to measure and report the estrogen (and progesterone) receptor in breast cancer. Int J Gynecol Cancer. 2006 Sep-Oct;16 Suppl 2:529-32.

Dirix LY, Dam PV, Prove A, Vermeulen PB. Inflammatory breast cancer: current understanding. Curr Opin Oncol. 2006 Nov;18(6):563-71.

Benoy IH, Elst H, Van Dam P, Scharpe S, Van Marck E, Vermeulen PB, Dirix LY. Detection of circulating tumour cells in blood by quantitative real-time RT-PCR: effect of pre-analytical time. Clin Chem Lab Med. 2006;44(9):1082-7.

Van der Auwera I, Colpaert C, Van Marck E, Vermeulen P, Dirix L. Lymphangiogenesis in breast cancer. Am J Surg Pathol. 2006 Aug;30(8):1055-6; author reply 1056-7.

Benoy IH, Elst H, Philips M, Wuyts H, Van Dam P, Scharpe S, Van Marck E, Vermeulen PB, Dirix LY. Prognostic significance of disseminated tumor cells as detected by quantitative real-time reverse-transcriptase polymerase chain reaction in patients with breast cancer. Clin Breast Cancer. 2006 Jun;7(2):146-52.

Van Laere SJ, Van der Auwera I, Van den Eynden GG, Elst HJ, Weyler J, Harris AL, van Dam P, Van Marck EA, Vermeulen PB, Dirix LY. Nuclear factor-kappaB signature of inflammatory breast cancer by cDNA microarray validated by quantitative real-time reverse transcription-PCR, immunohistochemistry, and nuclear factor-kappaB DNA-binding.Clin Cancer Res. 2006 Jun 1;12(11 Pt 1):3249-56.

Perryman LA, Blair JM, Kingsley EA, Szymanska B, Ow KT, Wen VW, Mackenzie KL, Vermeulen PB, Jackson P, Russell PJ. Over-expression of p53 mutants in LNCaP cells alters tumor growth and angiogenesis in vivo. Biochem Biophys Res Commun. 2006 May 11; [Epub ahead of print]

Van den Eynden GG, Van der Auwera I, Van Laere SJ, Colpaert CG, van Dam P, Dirix LY, Vermeulen PB, Van Marck EA. Distinguishing blood and lymph vessel invasion in breast cancer: a prospective immunohistochemical study. Br J Cancer. 2006 May 2; [Epub ahead of print]

Benoy IH, Elst H, Philips M, Wuyts H, Van Dam P, Scharpe S, Van Marck E,Vermeulen PB, Dirix LY. Real-time RT-PCR detection of disseminated tumour cells in bone marrow has superior prognostic significance in comparison with circulating tumour cells in patients with breast cancer. Br J Cancer. 2006 Mar 13;94(5):672-680.

de Jong KP, Vermeulen PB, van Marck E, Boot M, Gouw AS. Endothelial cell apoptosis in the context of quantification of angiogenesis in solid human adenocarcinomas: A novel double immunolabelling technique to identify endothelial cell apoptosis. Eur J Cancer. 2006 Jan;42(1):97-100. Epub 2005 Dec 5.

2005

Van den Eynden GG, Van der Auwera I, Van Laere SJ, Colpaert CG, Turley H, Harris AL, van Dam P, Dirix LY, Vermeulen PB and Van Marck EA. Angiogenesis and hypoxia in lymph node metastases is predicted by the angiogenesis and hypoxia in the primary tumour in patients with breast cancer. Br J Cancer. 2005 Nov 14;93(10):1128-1136.

Van der Auwera I, Van den Eynden GG, Colpaert CG, Van Laere SJ, van Dam P, Van Marck EA, Dirix LY and Vermeulen PB.Tumor lymphangiogenesis in inflammatory breast carcinoma: a histomorphometric study. Clin Cancer Res. 2005 Nov 1;11(21):7637-42.

Van Laere SJ, Van den Eynden GG, Van der Auwera I, Vandenberghe M, Van Dam P, Van Marck EA, Van Golen KL, Vermeulen PB and Dirix LY. Identification of cell-of-origin breast tumor subtypes in Inflammatory Breast Cancer by gene expression profiling. Breast Cancer Res Treat. 2005 Oct 27;1-13 Epub ahead of print.

Van den Eynden GG, Van Laere SJ, Van der Auwera I, Merajver SD, Van Marck EA, van Dam P, Vermeulen PB, Dirix LY and van Golen KL. Overexpression of caveolin-1 and -2 in cell lines and in human samples of inflammatory breast cancer. Breast Cancer Res Treat. 2005 Oct 22;:1-10 [Epub ahead of print].

Luc Dirix, Peter Van Dam and Peter Vermeulen. Genomics and circulating tumor cells: promising tools for choosing and monitoring adjuvant therapy in patients with early breast cancer? Current Opinion in Oncology 2005 Nov;17(6):551-558.

Baak JP, Colpaert CG, van Diest PJ, Janssen E, Diermen BV, Albernaz E, Vermeulen PB, Van Marck EA. Related Articles, Links Multivariate prognostic evaluation of the mitotic activity index and fibrotic focus in node-negative invasive breast cancers. Eur J Cancer. 2005 Sep 6; [Epub ahead of print].

Van Laere S, Van der Auwera I, Van den Eynden GG, Fox SB, Bianchi F, Harris AL, van Dam P, Van Marck EA, Vermeulen PB and Dirix LY. Distinct molecular signature of inflammatory breast cancer by cDNA microarray analysis. Breast Cancer Res. Treat. 2005 Aug 22; [Epub ahead of print].

Sardari Nia P, Weyler J, Colpaert C, Vermeulen P, Van Marck E, Van Schil P. Related Articles, Links Prognostic value of smoking status in operated non-small cell lung cancer. Lung Cancer. 2005 Mar;47(3):351-9.

Benoy I, Salgado R, Elst H, Van Dam P, Weyler J, Van Marck E, Scharpe S, Vermeulen P and Dirix L. Relative microvessel area of the primary tumour, and not lymph node status, predicts the presence of bone marrow micrometastases detected by reverse transcriptase polymerase chain reaction in patients with clinically non-metastatic breast cancer. Breast Cancer Res. Treat. 2005;7(2):R210-9. Epub 2005 Jan 10.

2004

Van der Auwera I, Van Laere SJ, Van den Eynden GG, Benoy I, Van Dam P, Colpaert CG, Fox SB, Turley H, Harris AL, Van Marck EA, Vermeulen PB and Dirix LY. Increased angiogenesis and lymphangiogenesis in inflammatory versus non-inflammatory breast cancer by real-time RT-PCR gene expression quantification. Clin Cancer Res 2004, Dec 1;10(23):7965-71.

Van der Auwera I, Vermeulen P, Van Marck E, Dirix L. Lack of lymphangiogenesis during breast carcinogenesis. J Clin Pathol. 2004 Dec;57(12):1342-3.

Benoy IH, Salgado R, Van Dam P, Geboers K, Van Marck E, Scharpé S, Vermeulen PB, Dirix LY. Increased serum Interleukin-8 in patients with early and metastatic breast cancer correlates with early dissemination and survival. Clin Cancer Res. 2004 Nov 1;10(21):7157-62

Benoy IH, Elst H, Van der Auwera I, Van Laere S, van Dam P, Van Marck E, Scharpé S, Vermeulen PB and Dirix LY. Real-time RT-PCR correlates with immunocytochemistry for the detection of disseminated epithelial cells in bone marrow aspirates of patients with breast cancer. Br J Cancer. 2004 Nov 15;91(10):1813-20.

Sardari Nia P, Colpaert C, Blyweert B, Kui B, Vermeulen P, Ferguson M, Hendriks J, Weyler J, Pezzella F, Van Marck E, Schil PV. Prognostic value of nonangiogenic and angiogenic growth patterns in non-small-cell lung cancer. Br J Cancer. 2004 Aug 24.

Salgado R, Benoy I, Vermeulen P, Van Dam P, Van Marck E, Dirix L. Circulating Basic Fibroblast Growth Factor is Partly Derived from the Tumour in Patients with Colon, Cervical and Ovarian Cancer. Angiogenesis. 2004;7(1):29-32.

Salgado R, Vermeulen P, Dirix LY. Elevated perioperative serum vascular endothelial growth factor levels in patients with colon carcinoma. Cancer. 2004 Jul 15;101(2):431-2; author reply 432-3.

Weyn B, Tjalma WA, Vermeulen P, van Daele A, Van Marck E, Jacob W. Determination of tumour prognosis based on angiogenesis-related vascular patterns measured by fractal and syntactic structure analysis. Clin Oncol (R Coll Radiol). 2004 Jun;16(4):307-16.

De Raeve HR, Vermeulen PB, Vanderkerken K, Harris AL, Van Marck E. Microvessel density, endothelial-cell proliferation and carbonic anhydrase IX expression in haematological malignancies, bone-marrow metastases and monoclonal gammopathy of undetermined significance. Virchows Arch. 2004 May; 445:27-35.

Stessels F, Van den Eynden G, Van der Auwera I, Salgado R, Van den Heuvel E, Harris AL, Jackson DG, Colpaert CG, van Marck EA, Dirix LY, Vermeulen PB. Breast adenocarcinoma liver metastases, in contrast to colorectal cancer liver metastases, display a non-angiogenic growth pattern that preserves the stroma and lacks hypoxia. Br J Cancer. 2004 Apr 5;90(7):1429-36.

Van den Eynden GG, Van der Auwera I, Van Laere S, Colpaert CG, Van Dam P, Merajver S, Kleer CG, Harris AL, Van Marck EA, Dirix LY, Vermeulen PB. Validation of a tissue microarray to study differential protein expression in inflammatory and non-inflammatory breast cancer. Breast Cancer Res Treat. 2004 May;85(1):13-22.

2003

Colpaert CG, Vermeulen PB, Fox SB, Harris AL, Dirix LY, Van Marck EA. The presence of a fibrotic focus in invasive breast carcinoma correlates with the expression of carbonic anhydrase IX and is a marker of hypoxia and poor prognosis. Breast Cancer Res Treat. 2003 Sep;81(2):137-47.

Sardari Nia P, Stessels F, Pezzella F, Vermeulen PB, van Marck EA, van Schil P. Growth index is independent of microvessel density in non-small cell lung carcinomas.Hum Pathol. 2003 Sep;34(9):959-60; author reply 960-1.

Colpaert CG, Vermeulen PB, Dirix LY, Van Marck EA. Commentary re: N. J. McCarthy et al., microvessel density, expression of estrogen receptor alpha, MIB-1, p53 and c-erbB-2 in inflammatory breast cancer. Clin. Cancer Res., 8: 3857-3862, 2002. Clin Cancer Res. 2003 Sep 1;9(10 Pt 1):3815-6; author reply 3816.

Colpaert CG, Vermeulen PB, Van Beest P, Soubry A, Goovaerts G, Dirix LY, Harris AL, Van Marck EA. Cutaneous breast cancer deposits show distinct growth patterns with different degrees of angiogenesis, hypoxia and fibrin deposition. Histopathology. 2003 Jun;42(6):530-40.

Colpaert CG, Vermeulen PB, Benoy I, Soubry A, van Roy F, van Beest P, Goovaerts G, Dirix LY, van Dam P, Fox SB, Harris AL, van Marck EA. Inflammatory breast cancer shows angiogenesis with high endothelial proliferation rate and strong E-cadherin expression. Br J Cancer. 2003 Mar 10;88(5):718-25.

Salgado R, Junius S, Benoy I, Van Dam P, Vermeulen P, Van Marck E, Huget P, Dirix LY. Circulating interleukin-6 predicts survival in patients with metastatic breast cancer. Int J Cancer. 2003 Feb 20;103(5):642-6.

2002

Salgado R, Benoy I, Weytjens R, Van Bockstaele D, Van Marck E, Huget P, Hoylaerts M, Vermeulen P, Dirix LY. Arterio-venous gradients of IL-6, plasma and serum VEGF and D-dimers in human cancer. Br J Cancer. 2002 Dec 2;87(12):1437-44.

Van den Eynden GG, Colpaert CG, Vermeulen PB, Weyler JJ, Goovaerts G, van Dam P, Van Marck EA, Dirix LY. Comparative analysis of the biochemical and immunohistochemical determination of hormone receptors in invasive breast carcinoma influence of the tumor-stroma ratio. Pathol Res Pract. 2002;198(8):517-24.

Salgado R, Benoy I, van Marck E, Vermeulen P, Dirix L. The importance of the VEGF-load in platelets in cancer patients. Ann Oncol. 2002 Oct;13(10):1689-90.

Vermeulen PB, Fox SB, Dirix LY, Colpaert C, Van Marck EA. Heterogeneity of vascularisation in invasive breast carcinoma. Eur J Cancer. 2002 Sep;38(14):1951-2.

Vermeulen PB, Gasparini G, Fox SB, Colpaert C, Marson LP, Gion M, Belien JA, de Waal RM, Van Marck E, Magnani E, Weidner N, Harris AL, Dirix LY. Second international consensus on the methodology and criteria of evaluation of angiogenesis quantification in solid human tumours. Eur J Cancer. 2002 Aug;38(12):1564-79. Review.

Salgado R, Benoy I, Dirix L, Vermeulen P, Van Marck E. Importance of platelets in VEGF-mediated angiogenesis in tumors. FEBS Lett. 2002 Jun 5;520(1-3):182.

Dirix LY, van Oosterom AT. Gene-expression profiling to classify soft-tissue sarcomas. Lancet. 2002 Apr 13;359(9314):1263-4.

Vermeulen PB, Sardari Nia P, Colpaert C, Dirix LY, Van Marck E. Lack of angiogenesis in lymph node metastases of carcinomas is growth pattern-dependent. Histopathology. 2002 Jan;40(1):105-7.

Benoy I, Salgado R, Colpaert C, Weytjens R, Vermeulen PB, Dirix LY. Serum interleukin 6, plasma VEGF, serum VEGF, and VEGF platelet load in breast cancer patients. Clin Breast Cancer. 2002 Jan;2(4):311-5.

Dirix LY, Salgado R, Weytjens R, Colpaert C, Benoy I, Huget P, van Dam P, Prove A, Lemmens J, Vermeulen P. Plasma fibrin D-dimer levels correlate with tumour volume, progression rate and survival in patients with metastatic breast cancer. Br J Cancer. 2002 Feb 1;86(3):389-95.

2001

Salgado R, Benoy I, Bogers J, Weytjens R, Vermeulen P, Dirix L, Van Marck E. Platelets and vascular endothelial growth factor (VEGF): a morphological and functional study. Angiogenesis. 2001;4(1):37-43.

Colpaert C, Vermeulen P, Van Marck E, Dirix L.The presence of a fibrotic focus is an independent predictor of early metastasis in lymph node-negative breast cancer patients. Am J Surg Pathol. 2001 Dec;25(12):1557-8.

Colpaert C, Vermeulen P, van Beest P, Goovaerts G, Weyler J, Van Dam P, Dirix L, Van Marck E. Intratumoral hypoxia resulting in the presence of a fibrotic focus is an independent predictor of early distant relapse in lymph node-negative breast cancer patients.Histopathology. 2001 Oct;39(4):416-25.

Vermeulen PB, Colpaert C, Salgado R, Royers R, Hellemans H, Van Den Heuvel E, Goovaerts G, Dirix LY, Van Marck E. Liver metastases from colorectal adenocarcinomas grow in three patterns with different angiogenesis and desmoplasia. J Pathol. 2001 Oct;195(3):336-42.

Salgado R, Vermeulen PB, Van Marck E, Benoy I, Dirix L. Correspondence re: M. L. George et al., Correlation of plasma and serum vascular endothelial growth factor levels with platelet count in colorectal cancer: clinical evidence of platelet scavenging? Clin. Cancer Res., 6: 3147-3152, 2000. Clin Cancer Res. 2001 May;7(5):1481-3.

Colpaert C, Vermeulen P, Jeuris W, van Beest P, Goovaerts G, Weyler J, Van Dam P, Dirix L, Van Marck E. Early distant relapse in "node-negative" breast cancer patients is not predicted by occult axillary lymph node metastases, but by the features of the primary tumour. J Pathol. 2001 Apr;193(4):442-9.

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